Design, Synthesis, Antimicrobial and Anticancer Activity of some Novel Benzoxazole-Isatin Conjugates
No Thumbnail Available
Date
2022
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
A series of novel benzoxazole-isatin conjugates were synthesized by treating 2-amino
benzoxazole with 5 and 7 substituted isatin derivatives and were screened for in vitro antimicrobial and
cytotoxic activities. The results showed that all the synthesized compounds shown mild to potent
antibacterial activity. The MIC values were found between 10 and 100 µg/ml against tested bacterial
and fungal organisms. Among all the compounds, 3d & 3c showed good antimicrobial. In vitro
cytotoxic activities were evaluated by MTT assay of all the test compounds against the different human
cancer cell lines. The compounds having substitution with electron-withdrawing groups (halides) at the
5th position on the isatin ring showed the most significant biological activity than substituted at the 7th
position. The molecular docking interactions have shown good binding interactions with the protein
targets glucosamine-6-phosphate synthase (GlcN-6-P synthase) and telomerase.