H2O2‑Mediated Synthesis of a Quinazolin-4(3H)‑one Scaffold: A Sustainable Approach
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Date
2023
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Publisher
American Chemical Society
Abstract
A quinazolin-4(3H)-one ring system is a privileged heterocyclic moiety with distinctive biological properties. From
this perspective, the development of an efficient strategy for the synthesis of quinazolin-4(3H)-one has always been in demand for
the synthetic chemistry community. In this report, we envisaged an efficient protocol for the synthesis of quinazolin-4(3H)-one using
substituted 2-amino benzamide with dimethyl sulfoxide (DMSO) as a carbon source and H2O2 as an effective oxidant.
Mechanistically, the reaction proceeds through the radical approach with DMSO as one carbon source. To further substantiate the
synthetic claim, the synthetic protocol has been extended to the synthesis of the anti-endotoxic active compound 3-(2-
carboxyphenyl)-4-(3H)-quinazolinone.